Complete Filing Data
Upstream Bio, Inc. reported Stockholders Equity of $339.77 million for FY2025.
All values from 10-K, 20-F, and 10-Q filings on SEC EDGAR, organized by financial statement. Scroll each table horizontally for the full history. Blank cells mean Upstream Bio, Inc. did not report that metric for that period in XBRL — often because accounting standards changed which tag a company files under (for example, most companies moved revenue to the ASC-606 tag in 2018), so a metric may continue in a different row. Rows marked * merge those successor tags into one continuous series, preferring the audited value from the newest-standard tag where periods overlap.
Income Statement
Annual (10-K / 20-F)
| Metric \ Fiscal Year | FY2025 | FY2024 | FY2023 |
|---|---|---|---|
| Net Income * | -$143.4M | -$62.8M | -$20.5M |
| Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax | $555.0K | -$46.0K | $21.0K |
| Revenue From Contract With Customer Excluding Assessed Tax | $2.9M | $2.4M | $2.4M |
| Research And Development Expense | $136.8M | $63.0M | $31.8M |
| Operating Income Loss | -$160.4M | -$77.8M | -$40.1M |
| Operating Expenses | $163.2M | $80.1M | $42.5M |
| Nonoperating Income Expense | $16.9M | $15.0M | $19.6M |
| Net Income Loss Available To Common Stockholders Basic | -$143.4M | -$76.4M | -$38.3M |
| General And Administrative Expense | $26.4M | $17.2M | $10.7M |
| Comprehensive Income Net Of Tax | -$142.9M | -$62.9M | -$20.5M |
| Other Nonoperating Income Expenses | -$15.0K | -$24.0K | -$115.0K |
| Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent | $555.0K | -$46.0K | $21.0K |
Quarterly (10-Q, single quarters)
| Metric \ Quarter | Q3 2025 | Q2 2025 | Q1 2025 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|
| Net Income * | -$33.7M | -$40.0M | -$27.3M | -$16.0M | -$14.7M | -$10.9M | -$3.1M | -$2.5M | -$3.1M |
| Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax | $235.0K | -$110.0K | $393.0K | $406.0K | -$34.0K | -$42.0K | -$19.0K | -$58.0K | |
| Revenue From Contract With Customer Excluding Assessed Tax | $683.0K | $937.0K | $566.0K | $607.0K | $510.0K | $640.0K | $621.0K | ||
| Research And Development Expense | $33.0M | $37.9M | $25.8M | $15.4M | $14.1M | $11.7M | $7.8M | ||
| Operating Income Loss | -$37.8M | -$44.3M | -$32.0M | -$18.9M | -$17.5M | -$15.0M | -$9.4M | ||
| Operating Expenses | $38.5M | $45.3M | $32.6M | $19.5M | $18.1M | $15.7M | $10.0M | ||
| Nonoperating Income Expense | $4.1M | $4.4M | $4.7M | $2.9M | $2.9M | $4.1M | $6.3M | ||
| Net Income Loss Available To Common Stockholders Basic | -$33.7M | -$40.0M | -$27.3M | -$21.0M | -$19.6M | -$14.0M | -$6.3M | ||
| General And Administrative Expense | $5.5M | $7.4M | $6.8M | $4.1M | $4.0M | $4.0M | $2.2M | ||
| Comprehensive Income Net Of Tax | -$33.5M | -$40.1M | -$26.9M | -$15.6M | -$14.7M | -$10.9M | -$3.1M | ||
| Other Nonoperating Income Expenses | -$19.0K | -$50.0K | -$3.0K | -$15.0K | -$6.0K | -$16.0K | |||
| Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent | $235.0K | -$110.0K | $393.0K | $406.0K | -$34.0K | -$42.0K |
Balance Sheet
Annual (10-K / 20-F)
| Metric \ Fiscal Year | FY2025 | FY2024 | FY2023 | FY2022 |
|---|---|---|---|---|
| Stockholders Equity | $339.8M | $469.9M | -$123.1M | -$106.2M |
| Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations | $101.8M | $326.1M | $25.8M | $17.1M |
| Redeemable Preferred Stock Dividends | $0.00 | $13.6M | $17.7M | |
| Change In Fair Value Of Preferred Stock Tranche Right Liabilities | $0.00 | $2.9M | $15.5M | |
| Cash And Cash Equivalents At Carrying Value | $101.6M | $325.9M | $25.8M | |
| Short Term Investments | $239.9M | $144.6M | $84.0M | |
| Retained Earnings Accumulated Deficit | -$334.2M | -$190.8M | -$128.0M | |
| Property Plant And Equipment Net | $559.0K | $582.0K | $159.0K | |
| Prepaid Expense And Other Assets Current | $9.6M | $8.1M | $7.1M | |
| Operating Lease Right Of Use Asset | $1.2M | $1.8M | $43.0K | |
| Operating Lease Liability Current | $720.0K | $704.0K | $45.0K | |
| Non Cash Lease Expense | $561.0K | $182.0K | $82.0K | |
| Liabilities Current | $13.5M | $10.7M | $6.5M | |
| Liabilities And Stockholders Equity | $353.8M | $481.7M | $117.2M | |
| Liabilities | $14.0M | $11.9M | $9.4M | |
| Common Stock Value | $54.0K | $53.0K | $3.0K | |
| Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect | -$224.3M | $300.3M | $8.8M | |
| Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents | $101.8M | $326.1M | $25.8M | |
| Assets Current | $351.8M | $479.2M | $117.0M | |
| Assets | $353.8M | $481.7M | $117.2M | |
| Accumulated Other Comprehensive Income Loss Net Of Tax | $530.0K | -$25.0K | $21.0K | |
| Accrued Liabilities And Other Liabilities | $10.0M | $6.0M | $4.5M | |
| Accretion Amortization Of Discounts And Premiums Investments | $1.5M | $1.7M | $1.3M | |
| Accounts Receivable Net Current | $668.0K | $613.0K | $98.0K | |
| Accounts Payable Current | $2.7M | $4.0M | $2.0M | |
| Restricted Cash Noncurrent | $194.0K | $194.0K | ||
| Operating Lease Liability Noncurrent | $549.0K | $1.1M | ||
| Right Of Use Asset Obtained In Exchange For Operating Lease Liability | $0.00 | $1.9M | $36.0K | |
| Net Change In Initial Public Offering Costs Accrued But Not Paid | $0.00 | $34.0K | ||
| Temporary Equity Carrying Amount Attributable To Parent | $0.00 | $230.9M | ||
| Temporary Equity Liquidation Preference | $267.7M |
Quarterly (10-Q, single quarters)
| Metric \ Quarter | Q3 2025 | Q2 2025 | Q1 2025 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|
| Stockholders Equity | $378.6M | $408.7M | $445.6M | -$160.3M | -$146.6M | -$133.4M | -$112.2M | -$109.9M | -$107.9M |
| Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations | $72.4M | $45.7M | $71.5M | $33.1M | $47.3M | $31.5M | $47.3M | ||
| Redeemable Preferred Stock Dividends | $0.00 | $0.00 | $5.0M | $4.9M | $3.1M | $3.2M | |||
| Change In Fair Value Of Preferred Stock Tranche Right Liabilities | $0.00 | $0.00 | $0.00 | $0.00 | $2.9M | $4.8M | |||
| Cash And Cash Equivalents At Carrying Value | $72.2M | $45.5M | $71.3M | $32.9M | $47.3M | $31.5M | $47.3M | ||
| Short Term Investments | $300.3M | $348.1M | $360.1M | $187.7M | |||||
| Retained Earnings Accumulated Deficit | -$291.8M | -$258.0M | -$218.1M | -$169.5M | |||||
| Property Plant And Equipment Net | $616.0K | $544.0K | $539.0K | $578.0K | |||||
| Prepaid Expense And Other Assets Current | $15.9M | $23.8M | $21.8M | $6.0M | |||||
| Operating Lease Right Of Use Asset | $1.4M | $1.5M | $1.6M | $1.9M | |||||
| Operating Lease Liability Current | $716.0K | $712.0K | $708.0K | $678.0K | |||||
| Non Cash Lease Expense | $134.0K | $21.0K | |||||||
| Liabilities Current | $11.9M | $10.9M | $9.6M | $10.9M | |||||
| Liabilities And Stockholders Equity | $391.2M | $420.5M | $456.2M | $232.7M | |||||
| Liabilities | $12.6M | $11.8M | $10.6M | $12.1M | |||||
| Common Stock Value | $56.0K | $54.0K | $53.0K | $3.0K | |||||
| Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect | -$254.6M | $5.7M | |||||||
| Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents | $72.4M | $45.7M | $71.5M | $33.1M | $47.3M | $31.5M | $47.3M | ||
| Assets Current | $389.0M | $418.3M | $453.8M | $227.3M | |||||
| Assets | $391.2M | $420.5M | $456.2M | $232.7M | |||||
| Accumulated Other Comprehensive Income Loss Net Of Tax | $493.0K | $258.0K | $368.0K | $351.0K | |||||
| Accrued Liabilities And Other Liabilities | $7.2M | $7.7M | $4.1M | $5.3M | |||||
| Accretion Amortization Of Discounts And Premiums Investments | $1.7M | $623.0K | |||||||
| Accounts Receivable Net Current | $683.0K | $937.0K | $566.0K | $607.0K | |||||
| Accounts Payable Current | $4.0M | $2.6M | $4.7M | $4.9M | |||||
| Restricted Cash Noncurrent | $194.0K | $194.0K | $194.0K | $194.0K | |||||
| Operating Lease Liability Noncurrent | $703.0K | $849.0K | $992.0K | $1.3M | |||||
| Right Of Use Asset Obtained In Exchange For Operating Lease Liability | |||||||||
| Net Change In Initial Public Offering Costs Accrued But Not Paid | $52.0K | ||||||||
| Temporary Equity Carrying Amount Attributable To Parent | $380.9M | ||||||||
| Temporary Equity Liquidation Preference | $430.8M |
Cash Flow Statement
Annual (10-K / 20-F)
| Metric \ Fiscal Year | FY2025 | FY2024 | FY2023 |
|---|---|---|---|
| Share Based Compensation | $10.3M | $6.0M | $3.3M |
| Proceeds From Sale Maturity And Collection Of Shortterm Investments | $292.6M | $231.6M | $46.3M |
| Payments To Acquire Short Term Investments | $385.9M | $290.6M | $129.0M |
| Net Cash Provided By Used In Operating Activities | -$133.3M | -$59.2M | -$37.9M |
| Net Cash Provided By Used In Investing Activities | -$93.5M | -$59.5M | -$82.8M |
| Net Cash Provided By Used In Financing Activities | $2.4M | $418.9M | $129.6M |
| Increase Decrease In Prepaid Deferred Expense And Other Assets | $1.5M | $1.0M | $6.2M |
| Increase Decrease In Other Accounts Payable And Accrued Liabilities | $4.0M | $1.5M | $422.0K |
| Increase Decrease In Operating Lease Liability | -$565.0K | -$133.0K | -$82.0K |
| Increase Decrease In Accounts Payable | -$1.3M | $2.0M | $1.3M |
| Increase Decrease In Accounts And Notes Receivable | $55.0K | $515.0K | -$314.0K |
| Depreciation Depletion And Amortization | $188.0K | $89.0K | $60.0K |
| Proceeds From Stock Options Exercised | $2.3M | $159.0K | $118.0K |
| Payments To Acquire Property Plant And Equipment | $165.0K | $511.0K | $144.0K |
| Payments Of Stock Issuance Costs | $3.9M | ||
| Proceeds From Issuance Of Convertible Preferred Stock | $0.00 | $149.9M | |
| Proceeds From Issuance Initial Public Offering | $0.00 | $272.7M |
Quarterly (10-Q, single quarters)
| Metric \ Quarter | Q1 2025 | Q1 2024 |
|---|---|---|
| Share Based Compensation | $2.6M | $643.0K |
| Proceeds From Sale Maturity And Collection Of Shortterm Investments | $52.7M | $37.3M |
| Payments To Acquire Short Term Investments | $266.1M | $23.4M |
| Net Cash Provided By Used In Operating Activities | -$41.2M | -$17.6M |
| Net Cash Provided By Used In Investing Activities | -$213.4M | $13.9M |
| Net Cash Provided By Used In Financing Activities | -$34.0K | $9.4M |
| Increase Decrease In Prepaid Deferred Expense And Other Assets | $13.7M | $1.7M |
| Increase Decrease In Other Accounts Payable And Accrued Liabilities | -$1.9M | -$884.0K |
| Increase Decrease In Operating Lease Liability | -$134.0K | -$22.0K |
| Increase Decrease In Accounts Payable | $711.0K | -$615.0K |
| Increase Decrease In Accounts And Notes Receivable | -$47.0K | $640.0K |
| Depreciation Depletion And Amortization | $43.0K | $13.0K |
| Proceeds From Stock Options Exercised | $12.0K | |
| Payments To Acquire Property Plant And Equipment | ||
| Payments Of Stock Issuance Costs | $34.0K | |
| Proceeds From Issuance Of Convertible Preferred Stock | ||
| Proceeds From Issuance Initial Public Offering |
Per-Share & Share Counts
Annual (10-K / 20-F)
| Metric \ Fiscal Year | FY2025 | FY2024 | FY2023 |
|---|---|---|---|
| Weighted Average Number Of Shares Outstanding Basic | 53.9M | 13.7M | 3.0M |
| Weighted Average Number Of Diluted Shares Outstanding | 53.9M | 13.7M | 3.0M |
| Earnings Per Share Diluted | $-2.66 | $-5.58 | $-12.95 |
| Earnings Per Share Basic | $-2.66 | $-5.58 | $-12.95 |
| Common Stock Shares Outstanding | 54.2M | 53.6M | 3.0M |
| Common Stock Shares Issued | 54.2M | 53.6M | 3.0M |
| Common Stock Shares Authorized | 500.0M | 500.0M | 40.7M |
| Common Stock Par Or Stated Value Per Share | $0.00 | $0.00 | $0.00 |
| Preferred Stock Shares Outstanding | 0.00 | 0.00 | 0.00 |
| Preferred Stock Shares Issued | 0.00 | 0.00 | 0.00 |
| Preferred Stock Shares Authorized | 10.0M | 10.0M | 0.00 |
| Preferred Stock Par Or Stated Value Per Share | $0.00 | $0.00 | $0.00 |
| Temporary Equity Shares Outstanding | 22.9M | ||
| Temporary Equity Shares Issued | 22.9M | ||
| Temporary Equity Shares Authorized | 31.8M |
Quarterly (10-Q, single quarters)
| Metric \ Quarter | Q3 2025 | Q2 2025 | Q1 2025 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 |
|---|---|---|---|---|---|---|---|
| Weighted Average Number Of Shares Outstanding Basic | 53.9M | 53.8M | 53.6M | 3.0M | 3.0M | 3.0M | 3.0M |
| Weighted Average Number Of Diluted Shares Outstanding | 53.9M | 53.8M | 53.6M | 3.0M | 3.0M | 3.0M | 3.0M |
| Earnings Per Share Diluted | $-0.63 | $-0.74 | $-0.51 | $-6.96 | $-6.50 | $-4.68 | $-2.11 |
| Earnings Per Share Basic | $-0.63 | $-0.74 | $-0.51 | $-6.96 | $-6.50 | $-4.68 | $-2.11 |
| Common Stock Shares Outstanding | 54.0M | 53.8M | 53.6M | 3.0M | |||
| Common Stock Shares Issued | 54.0M | 53.8M | 53.6M | 3.0M | |||
| Common Stock Shares Authorized | 500.0M | 500.0M | 500.0M | 40.7M | |||
| Common Stock Par Or Stated Value Per Share | $0.00 | $0.00 | $0.00 | $0.00 | |||
| Preferred Stock Shares Outstanding | 0.00 | 0.00 | 0.00 | ||||
| Preferred Stock Shares Issued | 0.00 | 0.00 | 0.00 | ||||
| Preferred Stock Shares Authorized | 10.0M | 10.0M | 10.0M | ||||
| Preferred Stock Par Or Stated Value Per Share | $0.00 | $0.00 | $0.00 | ||||
| Temporary Equity Shares Outstanding | 31.8M | ||||||
| Temporary Equity Shares Issued | 31.8M | ||||||
| Temporary Equity Shares Authorized | 31.8M |
Other Metrics
Annual (10-K / 20-F)
| Metric \ Fiscal Year | FY2025 | FY2024 | FY2023 |
|---|---|---|---|
| Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value | $10.3M | $6.0M | $3.3M |
| Stock Issued During Period Value Stock Options Exercised Net Of Tax Withholding | $2.3M | $159.0K | $118.0K |
| Investment Income Interest | $16.9M | $12.1M | $4.2M |
| Additional Paid In Capital | $673.4M | $660.6M | $4.8M |
Quarterly (10-Q, single quarters)
| Metric \ Quarter | Q3 2025 | Q2 2025 | Q1 2025 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|
| Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value | $2.6M | $2.6M | $2.6M | $1.9M | $1.4M | $643.0K | $683.0K | $627.0K | $1.3M |
| Stock Issued During Period Value Stock Options Exercised Net Of Tax Withholding | $760.0K | $612.0K | $19.0K | $100.0K | $12.0K | $100.0K | $18.0K | ||
| Investment Income Interest | $4.1M | $4.4M | $4.7M | $2.9M | $2.9M | $1.3M | $1.5M | ||
| Additional Paid In Capital | $669.8M | $666.4M | $663.2M | $8.9M |
Most recent annual filing with the SEC: March 26, 2026
Data sourced from SEC EDGAR public filings as of August 5, 2026.