Quick Answer
IONIS PHARMACEUTICALS INC reported Operating Income of -$381.68 million for fiscal year 2025.
IONIS PHARMACEUTICALS INC Operating Income — Annual History
| Fiscal Year | Operating Income | YoY Change |
|---|---|---|
| 2025 | -$381.68M | +19.7% |
| 2024 | -$475.08M | -34.3% |
| 2023 | -$353.73M | +13.8% |
| 2022 | -$410.19M | -1258.9% |
| 2021 | -$30.19M | +82.5% |
| 2020 | -$172.08M | -147.0% |
| 2019 | $365.88M | +696.2% |
| 2018 | -$61.37M | -297.7% |
| 2017 | $31.05M | +254.0% |
| 2016 | -$20.16M | +73.4% |
| 2015 | -$75.76M | -58.7% |
| 2014 | -$47.73M | +7.6% |
| 2013 | -$51.67M | +25.0% |
| 2012 | -$68.92M | +3.1% |
| 2011 | -$71.10M | -47.0% |
| 2010 | -$48.36M | -75.6% |
| 2009 | -$27.54M | -110.9% |
| 2008 | -$13.06M | — |
Quarterly Operating Income
| Quarter Ending | Operating Income | YoY | QoQ |
|---|---|---|---|
| September 30, 2025 | -$160.18M | -7.8% | -214.6% |
| June 30, 2025 | $139.82M | +311.6% | +195.2% |
| March 31, 2025 | -$146.86M | +1.8% | +1.2% |
| September 30, 2024 | -$148.66M | -3.8% | -124.9% |
| June 30, 2024 | -$66.09M | +26.7% | +55.8% |
| March 31, 2024 | -$149.51M | -31.0% | -4.4% |
| September 30, 2023 | -$143.26M | -142.2% | -58.8% |
| June 30, 2023 | -$90.19M | -5.5% | +21.0% |
- IONIS PHARMACEUTICALS INC showed an increase of +19.7% in Operating Income compared to the prior fiscal year.
- Over the 2008–2025 period, IONIS PHARMACEUTICALS INC’s operating income has declined by 2822.5% (from -$13.06 million to -$381.68 million).
- The most recent figure is from IONIS PHARMACEUTICALS INC’s fiscal year 2025 report (Form 10-K), filed with the SEC on February 26, 2026.
- All figures are sourced from SEC EDGAR XBRL filings, last verified June 17, 2026.
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