Quick Answer
Upstream Bio, Inc. reported Operating Income of -$160.36 million for fiscal year 2025.
Upstream Bio, Inc. Operating Income — Annual History
| Fiscal Year | Operating Income | YoY Change |
|---|---|---|
| 2025 | -$160.36M | -106.2% |
| 2024 | -$77.76M | -93.9% |
| 2023 | -$40.11M | — |
Quarterly Operating Income
| Quarter Ending | Operating Income | YoY | QoQ |
|---|---|---|---|
| September 30, 2025 | -$37.83M | -100.3% | +14.7% |
| June 30, 2025 | -$44.35M | -152.8% | -38.5% |
| March 31, 2025 | -$32.01M | -113.2% | -69.4% |
| September 30, 2024 | -$18.89M | -101.3% | -7.7% |
| June 30, 2024 | -$17.54M | — | -16.8% |
| March 31, 2024 | -$15.01M | — | -60.0% |
| September 30, 2023 | -$9.39M | — | — |
- Upstream Bio, Inc. showed a decrease of -106.2% in Operating Income compared to the prior fiscal year.
- Over the 2023–2025 period, Upstream Bio, Inc.’s operating income has declined by 299.8% (from -$40.11 million to -$160.36 million).
- The most recent figure is from Upstream Bio, Inc.’s fiscal year 2025 report (Form 10-K), filed with the SEC on March 26, 2026.
- All figures are sourced from SEC EDGAR XBRL filings, last verified June 17, 2026.
Last verified: